An expedient, regioselective synthesis of novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their anticancer potential |
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Authors: | Manas Chakrabarty Taraknath Kundu Yoshihiro Harigaya |
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Affiliation: | a Department of Chemistry, Bose Institute, 93/1, A.P.C. Road, Kolkata 700 009, India b School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan |
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Abstract: | Several novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their 6-alkyl and 8-alkyl derivatives have been synthesised in high overall yields starting from 5-nitro and 6-nitroindazoles in a three-step route involving the regioselective cyclisation of thioureidoindazoles and indazolyl dithiocarbamates as the key steps. Some assorted thiazoloindazoles have been screened for anticancer properties, which demonstrated the anticancer potential of at least one product, justifying its further follow-up. |
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Keywords: | Thiazolo[5,4-e]- and -[4,5-g]indazoles Anticancer Regioselective synthesis Thioureidoindazoles Indazolyl dithiocarbamates Bromine in acetic acid |
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