CuI/L (L=pyridine-functionalized 1,3-diketones) catalyzed C-N coupling reactions of aryl halides with NH-containing heterocycles |
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Authors: | Zhenxing Xi |
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Institution: | Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, PR China |
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Abstract: | An efficient copper-catalyzed N-arylation and N-heteroarylation reactions of imidazole, pyrrole, indole, pyrazole, and perimidine with aryl or heteroaryl halides using pyridine-functionalized 1,3-diketone as ligands have been investigated. The ligands bearing pyridyl and 1,3-diketone moieties, which may form chelated Cu(I) species, are inexpensive and readily available. The combination of CuI and 1,3-di(pyridin-2-yl)propane-1,3-dione is very efficient for C-N coupling reactions to afford various N-arylated products in good to excellent yields. |
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Keywords: | Copper Pyridine-functionalized diones C-N coupling Heterocycles |
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