Synthesis of 2′-C-methyl-branched isonucleosides |
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Authors: | Tony Bouisset Richard Storer |
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Institution: | Laboratoire de Chimie Médicinale Idenix, Cap Gamma, 1682 rue de la Valsière, BP 50001, Montpellier, F-34189 Cedex 4, France |
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Abstract: | Novel regioisomers of 2′-methyl-branched nucleosides were designed and synthesized to mimic potent anti-viral drugs like Valopicitabine. The short and efficient synthesis of the targets involves a one-pot tosylation/cyclization step that leads to an activated furan scaffold on which the isonucleosides were built. |
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Keywords: | Nucleoside analogues Isonucleosides Valopicitabine Hepatitis C Anti-virals |
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