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DMSO-PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles |
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| Authors: | Céline Mousset Abdallah Hamze Jean-Daniel Brion |
| Institution: | a Univ Paris-Sud, CNRS, BioCIS, UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.B. Clément F-92296 Châtenay-Malabry, France b Institut de Chimie des Substances Naturelles, CNRS, avenue de la Terrasse, F-91198 Gif sur Yvette, France |
| Abstract: | PdI2 in DMSO promoted the oxidation of functionalized diarylalkynes into benzil derivatives in excellent yields. This new oxidation reaction was achieved with short reaction times and low loading of palladium catalyst. This efficient catalytic process has been applied successfully to the one-pot construction of a series of nitrogen-containing heterocycles of biological interest according to a tandem oxidation-nitrogen nucleophiles condensation-cyclization. |
| Keywords: | Benzils Palladium DMSO Alkynes Oxidation Tandem reactions Heterocyclic compounds |
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