Dolastanes from the brown alga Dilophus spiralis: absolute stereochemistry and evaluation of cytotoxicity |
| |
| Authors: | Efstathia Ioannou Constantinos Vagias |
| |
| Institution: | a Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
b Department of Didactics of Sciences, University of Jaén, PO 23071, Jaén, Spain |
| |
| Abstract: | Five new dolastanes (1-5) were isolated from the brown alga Dilophus spiralis. The structural elucidation of the isolated compounds and the assignment of relative stereochemistry were based on analyses of their spectroscopic data. The structure proposed for 1 was confirmed by single crystal X-ray diffraction analysis, whereas its absolute stereochemistry was determined using the modified Mosher's method. The cytotoxicity of 1-4 was evaluated against seven cell lines. |
| |
| Keywords: | Dilophus spiralis Dolastanes Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
