Catalyst-dependent syntheses of phosphatidylinositol-5-phosphate-DiC8 and its enantiomer |
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Authors: | Katherine J Kayser-Bricker |
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Institution: | Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520, USA |
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Abstract: | Peptide-based catalysts have been applied to the enantioselective syntheses of the title compounds, with this being the first report of the synthesis of an ent-PI5P analogue. The key steps in the synthesis involve asymmetric phosphorylation catalysis. Additional maneuvers were developed with a protecting groups scheme that enabled efficient, streamlined syntheses of these important mediators of biochemical events. |
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