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Cytosporin-related compounds from the marine-derived fungus Eutypella scoparia |
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| Authors: | Maria Letizia Ciavatta M Pilar Lopez-Gresa Rosario Nicoletti Ernesto Mollo Guido Cimino |
| Institution: | a Istituto di Chimica Biomolecolare, C.N.R., Pozzuoli 80078, Italy b Centro de Ecología Química Agrícola, Universidad Politécnica de Valencia, Campus de Vera, Edificio 6C, 46022 Valencia, Spain c Istituto Sperimentale per il Tabacco, C.R.A., Scafati 84018, Italy d State Key Laboratory of Drug Research, Institute of Materia Medica Shanghai, Institutes for Biological Sciences, Chinese Acadmy of Sciences, 201203 Shanghai, China |
| Abstract: | Chemical investigation of the culture broth of the fungus Eutypella scoparia ICB-OBX, isolated from the marine pulmonate mollusc Onchidium sp., led to the finding of novel compounds 1 and 2, structurally related to angiotensin II binding inhibitors cytosporins, along with unrelated known nitrogen metabolites (compounds 3-5). The structure and the relative stereochemistry of the novel metabolites were assigned mainly by a detailed analysis of two-dimensional NMR techniques whereas the absolute stereochemistry was proposed by modified Mosher's method. Compound 2 contains an unusual cyclic carbonate functionality that is rare among natural products. |
| Keywords: | Hexahydrobenzopyrane derivatives Cytosporins Marine fungus Eutypella scoparia Carbonate NMR Mosher method Pulmonata |
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