| O-糖基-甲氧甲酰基膦酰胺酯的合成及其生物活性研究 |
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| 引用本文： | 陈小茹,陈茹玉,李慧,毛丽娟. O-糖基-甲氧甲酰基膦酰胺酯的合成及其生物活性研究[J]. 高等学校化学学报, 1995, 16(12): 1899 |
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| 作者姓名： | 陈小茹 陈茹玉 李慧 毛丽娟 |
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| 作者单位： | 南开大学元素有机化学研究所, 天津, 300071 |
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| 基金项目： | 国家自然科学青年基金，天津市21世纪青年基金 |
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| 摘 要： | 合成了一系列新型O-糖基-甲氧甲酰基膦酰胺酯,并对O-糖基亚磷酰胺酯与氯甲酸甲酯的Arbuzov反应及其它有关反应进行了讨论。产物的结构经1HNMR、31PNMR、IR及元素分析确定。初步的生物活性测定结果表明,化合物3e对人肝癌Bel-7402细胞和人白血病HL-60细胞有一定的抑制作用。化合物3a对烟草花叶病毒有一定的抑制活性。
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| 关 键 词： | 甲酰基膦酰胺酯 Arbuzov反应 抗癌活性 抗病毒活性 |
| 收稿时间： | 1994-12-01 |
Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates |
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| CHEN Xiao-Ru,CHEN Ru-Yu,LI Hui,MAO Li-Juan. Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates[J]. Chemical Research In Chinese Universities, 1995, 16(12): 1899 |
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| Authors: | CHEN Xiao-Ru CHEN Ru-Yu LI Hui MAO Li-Juan |
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| Affiliation: | Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 |
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| Abstract: | A series of novel O-saccharidyl-methoxyformylphosphosphonamidates were synthesized,and Arbuzov reaetions of O-saccharidylphosphoramidites with methyl chloroformate and other related reactions were disussed.The structures of the products were determined by 1HNMR,31PNMR, IR and elemental analyses. The results of preliminary biological tests showed that compound 3cpossessed some inhibitory activities against Leukaemia HL-60 cells and liver cancer Bel-7402 cells in vitro,compound 3ahas some antivirus activity against tobacco mosaic virus(TMV). |
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| Keywords: | Formylphosphonamidate Arbuzov reaction Anticancer activity Antivirus activity |
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