金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定 |
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引用本文: | 彭花萍,余美玲,刘馨,刘盼,陈伟,刘爱林,林新华. 金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定[J]. 电化学, 2016, 22(1): 43. DOI: 10.13208/j.electrochem.150727 |
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作者姓名: | 彭花萍 余美玲 刘馨 刘盼 陈伟 刘爱林 林新华 |
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作者单位: | 1. 福建医科大学药学院药物分析系, 福建 福州 350108; 2. 福建省高等学校纳米医药技术重点实验室,福建 福州 350108 |
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基金项目: | 国家863计划资助项目(2012AA022604);国家自然科学基金(21405015,21275028);福建省自然科学基金资助项目(2014J05092);福建省教育厅项目(JA13147);大学生创新创业训练计划项目基金(201410392030) |
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摘 要: | 采用原位还原法制备金纳米粒子/聚多巴胺/碳纳米管(Au-PDA-MWNTs)复合材料,并将其用于建立高灵敏检测核黄素的电化学方法.采用紫外–可见光谱、扫描电镜、x-射线能谱对Au-PDA-MWNTs复合材料进行表征,采用循环伏安法和差示脉冲伏安法探讨核黄素(RF)在Au-PDA-MWNTs修饰的玻碳电极上的电化学行为,并对RF含量进行测定.该方法对核黄素的检测在5×10-9 mol·L-1~1×10-5 mol·L-1的范围内呈良好的线性关系(R=0.9906),检测限为1.7×10-9 mol·L-1.本方法操作简便、抗干扰能力强,方法可行,因此该方法成功实现了维生素药片中RF含量的测定.
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关 键 词: | 核黄素 金纳米粒子 聚多巴胺 多壁碳纳米管 电化学 |
收稿时间: | 2015-07-27 |
Fabrication of Riboflavin Electrochemical Sensor Based on Au Nanoparticles/Polydopamine/Carbon Nanotubes Modified Glassy CarbonElectrode |
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Abstract: | A novel electrochemical platform for the high sensitivity detection of riboflavin was constructed by Au nanoparticles/polydopamine/carbon nanotubes (Au-PDA-MWCNTs) nanocomposite modified glassy carbon electrode. The Au-PDA-MWCNTs nanocomposite was synthesized by in situ reduction method. The characteristics of the as-prepared Au-PDA-MWCNTs nanocomposite modified electrodes were investigated by using UV-Vis spectroscopy, scanning electron microscopy (SEM) and electrochemical methods. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to study the electrochemical behavior of riboflavin (RF) at Au-PDA-MWCNTs nanocomposite modified electrodes. The results demonstrated that the present electrochemical sensor exhibited a wide linear range from 5×10-9mol•L-1to 1×10-5 mol•L-1 for detection of riboflavin, with a detection limit of 1.7×10-9mol•L-1 (S/N = 3). The present method for high sensitivity determination of riboflavin by electrochemical method at Au-PDA-MWCNTs nanocomposite modified electrodes is simple, accurate, reliable and feasible with an excellent anti-interference ability against electroactive species and metal ions. Accordingly, the present method proved to be useful for the estimation of the RF content in pharmaceutical samples with satisfactory recovery. |
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Keywords: | riboflavin gold nanoparticles polydopamine multi-walled carbon nanotubes electrochemistry |
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