Synthesis and crystal structure of cytisino-N-(2-hydroxyethyl)-thiocarbamide |
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| Authors: | I. V. Kulakov O. A. Nurkenov D. M. Turdybekov A. A. Ainabaev K. M. Turdybekov A. M. Gazaliev |
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| Affiliation: | (1) Institute of Organic Synthesis and Coal Chemistry, Republic of Kazakhstan, ul. Alikhanova, 1, 100008 Karaganda, Kazakhstan;(2) Scientific Production Center Fitokhimiya, ul. Gazalieva, 4, Karaganda, Kazakhstan |
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| Abstract: | A thiourea derivative of the alkaloid cytisine was synthesized by reacting it with 1-propargyloxyethoxyethylisothiocyanate. It was shown that the synthesized acetal thiourea derivative underwent hydrolysis in acidic medium to cytisino-N-(2-hydroxyethyl)-thiocarbamide, the molecular structure of which was confirmed by an x-ray structure analysis. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 56–58, January–February, 2009. |
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| Keywords: | alkaloid cytisine acetal thiourea derivative isothiocyanates PMR spectroscopy x-ray structure analysis |
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