Electrochemical behaviour of tilmicosin at the hanging mercury drop electrode

The electrochemical behaviour of tilmicosin (TIM) was investigated using cyclic voltammetry and square-wave voltammetry in Britton-Robinson buffers (pH 2–12). The voltammograms of TIM showed one-irreversible peak which attributed to reduction of the >C=C< group in the entire pH values. However, an additional peak was shown over the pH range 2.00 to 4.00. Its peak potential is more positive potential from that of >C=C< group, and its potential was not practically dependent on the pH. On the other hand, the peak potential of >C=C< group was shifted to the more negative values with increasing pH. According to the obtained voltammetric data, the probable reaction mechanism for the reduction of TIM was proposed. Moreover, the adsorption of TIM on the mercury electrode surface by means of square-wave adsorptive stripping voltammetry measurements is studied at different pH values. The peak current variations with the deposition time and TIM concentration were observed.