Gas chromatographic determination of chlorothalonil and its metabolite 4-hydroxy-2,5,6-trichloroisophtalonitrile (HTI) in water |
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Authors: | C. van Doorn M. Vink J. M. van der Poll |
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Affiliation: | (1) Analysis Department, TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ Zeist, The Netherlands |
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Abstract: | Summary A gas chromatographic method, with electron capture detection and mass spectrometric confirmation, is described for the determination of chlorothalonil and its metabolite 4-hydroxy-2,5,6-trichloroisophtalonitrile (HTI) in water samples. Water is saturated with sodium chloride and acidified to pH<2 with dilute sulfuric acid. After extraction with dichloromethane, HTI was methylated with diazomethane. The extract obtained was cleaned with basic alumina. Chlorothalonil and the methylated HTI-derivative were determined by gas chromatography with electron capture detection (GC-ECD) and confirmed by gas chromatography-mass spectrometry (GC-MS). The limit of detection, depending on the nature of the water samples is for both compounds between 0.01–0.03 g 1–1 water. The average recovery in ground water is 87% for chlorothalonil and 82 % for HTI. |
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Keywords: | Gas chromatography-mass spectrometry Residue analysis Chlorothalonil 4-Hydroxy-2,5,6-trichloroisophtalonitrile (HTI) Water analysis |
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