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Expanding the scope of the Cu assisted Suzuki-Miyaura reaction |
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| Authors: | Brendan M. Crowley Craig M. PotteigerJames Z. Deng Christopher K. PrierDaniel V. Paone Christopher S. Burgey |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA |
| Abstract: | Recent advances in the development of the copper facilitated Suzuki-Miyaura reaction are described. Improvements include expansion of substrate scope to include aryl chlorides and polyhalo aryl boronates. It was found that use of S-Phos and X-Phos could accomplish the coupling of 2-pyridyl boronates to aryl chlorides and bromides in shorter reaction times and in higher yield than previously described with DPPF. |
| Keywords: | Suzuki-Miyaura 2-Pyridyl boronates Copper assisted reaction S-Phos Organometallic |
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