Inhibitorial effect of the Cu(II) and Ni(II) complexes with polyamines and imidazole derivatives on the Ca,Mg-dependent ATP-ase substrate |
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| Authors: | L.V. Tatjanenko Yu.Sh. Moshkovsky I.A. Zakharova G. Ponticelli M. Massacesi G. Devoto |
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| Affiliation: | Research Institute for Biological Tests of Chemical Compounds, Kupavna, Moscow, U.S.S.R.;S. N. Kurnakov Institute of General and Inorganic Chemistry, Academy of Science, Leninsky Prospect 31, Moscow, U.S.S.R.;Istituto di Chimica Generale ed Inorganica, Via Ospedale 72, Cagliari, Italy;Cattedra di Chimica A, Istituto di Medicina del Lavoro, Via S. Giorgio 12, Cagliari, Italy |
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| Abstract: | The investigation of the inhibitory activity on the Ca,Mg-dependent ATP-ase substrate of some Cu(II) and Ni(II) complexes with polyamines and imidazole derivatives is reported. These results show that the Cu(II) complexes have high inhibitorial effect with the exception of the following very stable compounds: square planar [Cu(N-PropIm)2(NCS)2], distorted octahedral [Cu(bipy)2(NCS)2] and five coordinate [Cu(Me6tren)(NCS)] (SCN). The Ni(II) derivatives present a medium inhibitorial activity except to the stable tetrahedral [Ni(N-PropIm)2(NCS)2], hexacoordinate [Ni(dpt)(tn)(NCS)] (SCN) and fivecoordinate [Ni(dpt)(tn)]Br2 and [Ni(Me6tren)(NCS)] (SCN). An explanation of these conclusions is reported. |
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| Keywords: | Author to whom correspondence should be addressed. |
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