| Design and Synthesis of Novel 5-Sulfoxide-substituted Pyrazolo[5,1-d] [1,2,3,5]tetrazin-4（3H）ones |
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| 作者姓名： | Yah Chao WU Xiao Mao ZOU Fang Zhong HU Hua Zheng YANG |
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| 作者单位： | [1]State Key Laboratory of Element-organic Chemistry, Institute of Element-organic Chemistry, Nankai University, Tianjin 300071 |
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| 基金项目： | We thank the National Natural Science Foundation of China （No. 20372040）, Fund of Tianjin Municipal Commission of Science and Technology （No. 043604111）, and the Chinese Research Fund for the Doctoral Program of High Education for financial supports. |
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| 摘 要： | A series of novel 5-sulfoxide-substituted pyrazolo5,1-d] 1,2,3,5]tetrazin-4（3H）ones 4a-j were designed and efficiently synthesized via a diazotization of 5-amine-3-methylsulfinyl- 1H-pyrazole, followed by cycloaddition with aryl isocyanate. A possible reaction mechanism is outlined and discussed. These new compounds exhibit some biological activity as preliminary bioassay indicated. Their structures were confirmed with ^1H NMR, IR and elemental analysis.
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| 关 键 词： | 亚砜 合成方法 重氮化作用 吡唑 环加成反应 芳基异氰酯 生物活性 结构表征 |
| 收稿时间： | 2004-10-18 |
Design and Synthesis of Novel 5-Sulfoxide-substituted Pyrazolo[5,1-d] [1,2,3,5]tetrazin-4(3H)ones |
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| Yah Chao WU Xiao Mao ZOU Fang Zhong HU Hua Zheng YANG.Design and Synthesis of Novel 5-Sulfoxide-substituted Pyrazolo[5,1-d] [1,2,3,5]tetrazin-4(3H)ones[J].Chinese Chemical Letters,2005,16(9):1143-1146. |
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| Authors: | Yah;Chao;WU;Xiao;Mao;ZOU;Fang;Zhong;HU;Hua;Zheng;YANG |
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| Abstract: | A series of novel 5-sulfoxide-substituted pyrazolo5,1-d]1,2,3,5]tetrazin-4(3H)ones 4a-j were designed and efficiently synthesized via a diazotization of 5-amine-3-methylsulfinyl- 1H-pyrazole, followed by cycloaddition with aryl isocyanate. A possible reaction mechanism is outlined and discussed. These new compounds exhibit some biological activity as preliminary bioassay indicated. Their structures were confirmed with 1H NMR, IR and elemental analysis. |
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| Keywords: | Sulfoxide-substituted nitrogen heterocycle diazotization cycloaddition |
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