| 微流控芯片非接触电导检测法测定药片中盐酸奈福泮 |
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| 引用本文： | 蔡自由,李永冲,陈缵光.微流控芯片非接触电导检测法测定药片中盐酸奈福泮[J].化学研究与应用,2011,23(8):1025-1029. |
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| 作者姓名： | 蔡自由 李永冲 陈缵光 |
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| 作者单位： | 1. 广东食品药品职业学院,广东 广州,510520
2. 中山大学药学院,广东 广州,510006 |
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| 基金项目： | 国家自然科学基金项目(20575080,20727006)资助 |
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| 摘 要： | 建立了微流控芯片非接触电导检测法测定片剂中盐酸奈福泮含量的方法.探讨并优化了缓冲溶液种类和配比、添加剂、分离电压和进样时间等电泳分离条件.结果表明,以2mmol/L HAc+1mmol/L NaAc( pH4.5)不加添加剂为运行缓冲溶液,分离电压2.00 kV、进样时间10 s时,1min内可实现盐酸奈福泮快速分离检...
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| 关 键 词： | 微流控芯片 非接触电导检测 盐酸奈福泮 |
Determination of nefopam hydrochloride in its tablets by microfluidic chip with contactless conductivity detection |
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| CAI Zi-you,LI Yong-chong,CHEN Zuan-guang.Determination of nefopam hydrochloride in its tablets by microfluidic chip with contactless conductivity detection[J].Chemical Research and Application,2011,23(8):1025-1029. |
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| Authors: | CAI Zi-you LI Yong-chong CHEN Zuan-guang |
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| Institution: | CAI Zi-you 1,LI Yong-chong 1,CHEN Zuan-guang2(1.Guangdong Food and Drug Vocational College,Guangzhou 510520,China,2.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China) |
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| Abstract: | A new method of microfluidic chip with contactless conductivity detection was established for the determination of nefopam hydrochloride in its tablets.The optimum separation electrophoretic conditions,such as the variety and concentration of buffer solution and additive,separation voltage and injection time etc,were researched.The results indicated that in the optimized running buffer of 2 mmol/L HAc+1 mmol/L NaAc(pH 4.5,no additive),nefopam hydrochloride was well separated and detected in 1 min at the sep... |
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| Keywords: | microfluidic chip contactless conductivity detection nefopam hydrochloride |
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