| (R)-/(S)-2-(5-氟尿嘧啶-1-基-乙酰基)氨基-3-羟基丙酸甲酯和DNA相互作用的电化学研究 |
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| 引用本文： | 张克军,刘武艺. (R)-/(S)-2-(5-氟尿嘧啶-1-基-乙酰基)氨基-3-羟基丙酸甲酯和DNA相互作用的电化学研究[J]. 化学研究与应用, 2011, 23(10): 1392-1395 |
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| 作者姓名： | 张克军 刘武艺 |
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| 作者单位： | 1. 阜阳师范学院生命科学学院,安徽阜阳236041;中国科学院青岛生物能源与过程研究所,山东青岛266101
2. 阜阳师范学院生命科学学院,安徽阜阳,236041 |
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| 基金项目： | 国家自然科学基金(31071310)资助项目; 安徽省教育厅自然科学基金(2006KJ224B)资助项目; 安徽高校优秀青年教师基金(2006jql222); 阜阳师院自然科学基金(2005QL11)联合资助项目 |
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| 摘 要： | 以自组装制得的DNA修饰电极为工作电极,采用循环伏安法以Fe(CN)63-/4-为电活性指示剂,研究了抗癌药物R型和S型的2-(5-氟尿嘧啶-1-基-乙酰基)氨基-3-羟基丙酸甲酯(简称为(R)-5FUSer和(S)-5FUSer)与DNA的相互作用.循环伏安测试结果表明:(1)体系的式电位随(R)-5FUSer和(S...
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| 关 键 词： | DNA (R)-5FUSer和(S)-5FUSer 循环伏安法 结合平衡常数 |
Electrochemical study of the interaction between methy(R)-/(S)-2-(5-fluorouracil-1-acetyl)amid 3-hydroxy propanoate and DNA |
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| ZHANG Ke-jun,LIU Wu-yi. Electrochemical study of the interaction between methy(R)-/(S)-2-(5-fluorouracil-1-acetyl)amid 3-hydroxy propanoate and DNA[J]. Chemical Research and Application, 2011, 23(10): 1392-1395 |
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| Authors: | ZHANG Ke-jun LIU Wu-yi |
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| Affiliation: | ZHANG Ke-jun1,2,LIU Wu-yi1(1.School of Biology Science,Fuyang Normal College,Fuyang 236041,China,(2.Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China) |
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| Abstract: | The Interaction between DNA and(R)/(S)-2-(5-fluorouracil-1-acetyl)amido-methyl-3-hydroxy propanoate(denoted as(R)-5FUSer and(S)-5FUSer)were investigated by cyclic voltammetry.The work electrode was DNA modified electrode based on self-assembly,in which Fe(CN)63-/4-were used as electroactive indictor.The experimental results indicated:(1)the peak potential shifts negatively with the increase of the concentration of(S)-5FUSer and(R)-5FUSer,suggesting that the interaction between DNA and(S)-5FUSer or(R)-5FUSer... |
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| Keywords: | DNA (R)-5FUSer and(S)-5FUSer cyclic voltammetry binding equilibrium constant. |
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