| 邻氯甲苯直接硝化法合成6-氯-3-氨基甲苯-4-磺酸 |
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| 引用本文： | 何二梅,姜日善.邻氯甲苯直接硝化法合成6-氯-3-氨基甲苯-4-磺酸[J].化学研究与应用,2011,23(9):1273-1274. |
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| 作者姓名： | 何二梅 姜日善 |
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| 作者单位： | 延边大学理学院化学系,吉林延吉,133002 |
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| 摘 要： | 邻氯甲苯混酸硝化合成6-氯-3-氨基甲苯-4-磺酸(CLT酸)因其产率低及选择性差而未能实现工业生产,本文对该工艺进行了改进,采用酸性β沸石和乙酰硝酸酯作为催化剂和硝化剂,提高了硝化选择性和收率,分别为72％和97％；并改进了还原、异构体分离和磺化操作；CLT酸总收率提高到61％.
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| 关 键 词： | CLT酸 硝化选择性 2-氯-5-氨基甲苯 |
Synthesis of 6-chloro-3-aminotoluene-4-sulfonic acid by direct nitration of o-chlorotoluene |
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| HE Er-mei,JIANG Ri-shan.Synthesis of 6-chloro-3-aminotoluene-4-sulfonic acid by direct nitration of o-chlorotoluene[J].Chemical Research and Application,2011,23(9):1273-1274. |
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| Authors: | HE Er-mei JIANG Ri-shan |
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| Institution: | HE Er-mei,JIANG Ri-shan(Department of chemistry,College of sciences,Yanbian University,Yanji 133002,China) |
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| Abstract: | Because of low yield and poor selectivity,direct nitration of o-chlorotoluene with mixed acid failed to achieve application in industrial synthesis of CLT acid.The use of zeolite-beta in its proton form as catalyist and acetyl nitrate as nitrating agent,increased the yield(97%)and selectivity of nitration(72%).And reduction,isomer separation and sulfonation process were improved.Overall yield of CLT acid was 61%. |
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| Keywords: | CLT acid selectivity of nitration 2-chloro-5-nitrotoluene |
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