两亲性嵌段共聚物mPEG-b-PCL/FA的合成及其药物释放性能

以苯甲醇为引发剂,在辛酸亚锡催化下引发ε-环己内酯(ε-CL )开环聚合,合成了聚己内酯(PCL).分别利用端甲氧基聚乙二醇(mPEG)、PCL及叶酸(FA)与三氯三嚎中不同的氯反应,得到两亲性嵌段共聚物mPEG-b-PCL/FA;采用傅立叶变换红外光谱仪和核磁共振谱仪等表征了mPEG-b-PCL/FA的组成和结构；采...

Synthesis of amphiphilic block copolymer mPEG-b-PCL/FA and evaluation of its drug-releasing performance

Polycaprolactone（PCL） was synthesized by the ring-opening polymerization of ε-caprolactone（ε-CL） in the presence of stannous octoate as catalyst and benzyl alcohol as macro-initiator.Then methoxypolyethylene glycol（mPEG）,PCL,and folic acid（FA） were separately allowed to substitute the chlorine atoms of trichlorimethiazide at different positions,generating amphiphilic block copolymer mPEG-b-PCL/FA.The composition and structure of as-synthesized amphiphilic block copolymer were characterized by means of Fourier transform infrared spectrometry and nuclear magnetic resonance spectroscopy（1H NMR）.The self-assembled behavior of the as-synthesized copolymer in water was studied by using a pyrene fluorescence probe and a transmission electron microscope.Results show that mPEG-b-PCL/FA in aqueous solution is able to self-assemble into nano-sized（100 nm） spherical micelle with a low critical micelle concentration of 2.13×10-3 g/L.In the meantime,model drug 5-fluorouracil（5-Fu） can be incorporated into the micelles,making it feasible for the drug to be released in a controlled manner.