(1) B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 68 F. Skorina Ave., Minsk, 220072, Belarus
Abstract:
Using spectrophotometric, spectral-luminescent, and polarization methods, we have detected the formation of strong equilibrium complexes of a key glycolytic enzyme — lactate dehydrogenase — with a promising photodynamic sensitizer — chlorin e6. It has been established that enzymes serve as the most sensitive targets destroying tumor cells subjected to photodynamic therapy.