组织胺敏感离子选择性微电极及其应用

合成了四对三氟甲基苯硼酸钠和三氟甲基苯硼－组织胺离子缔合牧，以该离子缔合物为对组织胺敏感的电活性物，进行了组织胺离子选择性的研究，同时制备了对 敏感的双通道离子选择性 电极，并对电极进行了考核。

Ion Selective Microelectrode for Histamine and Application

Anion selective microelectrode sensitive to histamine has been described in this paper. The synthesis of histamine sensitive 1iquid ion exchanger, being 5% (W/W) tetra(tri- fluoromethylphenyl)boron-histamine compounds dissolved in 3-nitro-xylol,and the fabrica- tion of corresponding two channel microelectrode based on such ion exchanger are reported. The calibration curves and their slopes, selectivity, stability and detection limits for different solutions are observed. Also, a rat hyperresponsive model is developed with intraperitoneally injection of ovalbumin. The ion selective electrode being discussed is used to detect respec- tively the concentration of histamine in rat mast cells before and 3 h. after a challenge with antigen.