Manganese‐Catalyzed Synthesis of cis‐β‐Amino Acid Esters through Organometallic CH Activation of Ketimines |
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Authors: | M?Sc Weiping Liu M?Sc Daniel Zell Dr Michael John Prof?Dr Lutz Ackermann |
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Institution: | Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstrasse 2, 37077 G?ttingen (Germany) http://www.org.chemie.uni‐goettingen.de/ackermann/ |
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Abstract: | Manganese‐catalyzed C? H functionalization reactions of ketimines set the stage for the expedient synthesis of cis‐β‐amino acid esters through site‐ and regioselective alkene annulations. The organometallic C? H activation occurred efficiently with high functional group tolerance, delivering densely functionalized β‐amino acid derivatives with ample scope. |
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Keywords: | amino acids C H activation manganese reaction mechanisms selectivity |
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