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Catalytic Enantioselective Synthesis of N,Cα,Cα‐Trisubstituted α‐Amino Acid Derivatives Using 1H‐Imidazol‐4(5H)‐ones as Key Templates |
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| Authors: | Julen Etxabe Joseba Izquierdo Dr. Aitor Landa Prof. Mikel Oiarbide Prof. Claudio Palomo |
| Affiliation: | Departamento de Química Orgánica I, Universidad del País Vasco UPV/EHU, Manuel Lardizabal 3, 20018 San Sebastián (Spain) |
| Abstract: | 1H‐Imidazol‐4(5H)‐ones are introduced as novel nucleophilic α‐amino acid equivalents in asymmetric synthesis. These compounds not only allow highly efficient construction of tetrasubstituted stereogenic centers, but unlike hitherto known templates, provide direct access to N‐substituted (alkyl, allyl, aryl) α‐amino acid derivatives. |
| Keywords: | amino acids asymmetric catalysis Michael additions organocatalysis synthetic methods |