The Organocatalytic Asymmetric Prins Cyclization |
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| Authors: | Dr Gavin Chit Tsui Luping Liu Prof Dr Benjamin List |
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| Institution: | Max‐Planck‐Institut für Kohlenforschung, Kaiser‐Wilhelm‐Platz 1, 45470 Mülheim an der Ruhr (Germany) |
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| Abstract: | We describe here the design and development of an organocatalytic Prins cyclization. In the presence of a confined chiral imidodiphosphoric acid catalyst, salicylaldehydes react with 3‐methyl‐3‐buten‐1‐ol to afford highly functionalized 4‐methylenetetrahydropyrans in excellent regio‐ and enantioselectivity. The extreme steric demand of the acid catalyst is key for the success of this transformation. |
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| Keywords: | asymmetric catalysis Brø nsted acids organocatalysis Prins cyclization tetrahydropyrans |
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