Regioselective Acceptorless Dehydrogenative Coupling of N‐Heterocycles toward Functionalized Quinolines,Phenanthrolines, and Indoles |
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Authors: | Dinesh Talwar Angela Gonzalez‐de‐Castro Dr Ho Yin Li Prof Jianliang Xiao |
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Institution: | Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD (UK) http://pcwww.liv.ac.uk/~xiao |
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Abstract: | A new strategy has been developed for the oxidant‐ and base‐free dehydrogenative coupling of N‐heterocycles at mild conditions. Under the action of an iridium catalyst, N‐heterocycles undergo multiple sp3 C? H activation steps, generating a nucleophilic enamine that reacts in situ with various electrophiles to give highly functionalized products. The dehydrogenative coupling can be cascaded with Friedel–Crafts addition, resulting in a double functionalization of the N‐heterocycles. |
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Keywords: | C C coupling C H functionalization dehydrogenation iridium complexes N‐heterocycles |
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