Organocatalytic Enantioselective Oxidative CH Alkenylation and Arylation of N‐Carbamoyl Tetrahydropyridines and Tetrahydro‐β‐carbolines |
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Authors: | Xigong Liu Zhilin Meng Chengkun Li Prof Hongxiang Lou Prof Lei Liu |
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Institution: | Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012 (P.R. China) |
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Abstract: | The first organocatalytic enantioselective C? H alkenylation and arylation reactions of N‐carbamoyl tetrahydropyridines and tetrahydro‐β‐carbolines (THCs) are described. The metal‐free processes represent an efficient and straightforward approach to a variety of structurally and electronically diverse α‐substituted tetrahydropyridines and THCs in good yields with excellent regio‐ and enantioselectivities. Preliminary control experiments provide important insights into the reaction mechanism. |
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Keywords: | asymmetric organocatalysis carbamates C H functionalization tetrahydropyridines tetrahydro‐β ‐carbolines |
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