|
|||||
|
|
Enantioselective Synthesis of Macrocyclic Heterobiaryl Derivatives of Molecular Asymmetry by Molybdenum‐Catalyzed Asymmetric Ring‐Closing Metathesis |
|
| Authors: | Yoichi Okayama Satoru Tsuji Yuka Toyomori Prof?Dr Atsunori Mori Dr Sachie Arae Dr Wei‐Yi Wu Prof?Dr Tamotsu Takahashi Prof?Dr Masamichi Ogasawara |
| Institution: | 1. Department of Chemical Science and Engineering, Kobe University, 1‐1 Rokkodai, Nada, Kobe 657‐8501 (Japan);2. Catalysis Research Center and Graduate School of Life Science, Hokkaido University, Kita21, Nishi10, Kita‐ku, Sapporo 001‐0021 (Japan) |
| Abstract: | Winding vine‐shaped molecular asymmetry is induced by enantioselective ring‐closing metathesis with a chiral molybdenum catalyst. The reaction proceeds under mild conditions through an E‐selective ring‐closing metathesis leading to macrocyclic bisazoles with enantioselectivities of up to 96 % ee. |
| Keywords: | asymmetric catalysis bisimidazoles molybdenum catalyst molecular asymmetry ring‐closing metathesis |