Free‐Standing Gold‐Nanoparticle Monolayer Film Fabricated by Protein Self‐Assembly of α‐Synuclein |
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| Authors: | Junghee Lee Dr. Ghibom Bhak Dr. Ji‐Hye Lee Woohyun Park Minwoo Lee Dr. Daekyun Lee Prof. Noo Li Jeon Prof. Dae H. Jeong Prof. Kookheon Char Prof. Seung R. Paik |
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| Affiliation: | 1. School of Chemical and Biological Engineering, Institute of Chemical Processes, College of Engineering, Seoul National University, Seoul 151‐744 (Korea);2. School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151‐744 (Korea);3. Department of Chemistry Education, Seoul National University, Seoul 151‐744 (Korea) |
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| Abstract: | Free‐standing nanoparticle films are of great importance for developing future nano‐electronic devices. We introduce a protein‐based fabrication strategy of free‐standing nanoparticle monolayer films. α‐Synuclein, an amyloidogenic protein, was utilized to yield a tightly packed gold‐nanoparticle monolayer film interconnected by protein β‐sheet interactions. Owing to the stable protein–protein interaction, the film was successfully expanded to a 4‐inch diameter sheet, which has not been achieved with any other free‐standing nanoparticle monolayers. The film was flexible in solution, so it formed a conformal contact, surrounding even microspheres. Additionally, the monolayer film was readily patterned at micrometer‐scale and thus unprecedented double‐component nanoparticle films were fabricated. Therefore, the free‐floating gold‐nanoparticle monolayer sheets with these properties could make the film useful for the development of bio‐integrated nano‐devices and high‐performance sensors. |
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| Keywords: | nanoparticles protein– protein interactions self‐assembly supramolecular chemistry thin films |
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