The Nucleoside Uridine Isolated in the Gas Phase |
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| Authors: | Dr Isabel Peña Dr Carlos Cabezas Prof José L Alonso |
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| Institution: | Grupo de Espectroscopía Molecular (GEM), Edificio Quifima, Laboratorio de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico Uva, Universidad de Valladolid, 47011 Valladolid (Spain) http://www.gem.uva.es |
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| Abstract: | Herein we present the first experimental observation of the isolated nucleoside uridine, placed in the gas phase by laser ablation and characterized by Fourier transform (FT) microwave techniques. Free from the bulk effects of their native environments, anti/C2′‐endo‐g+ conformation has been revealed as the most stable form of uridine. Intramolecular hydrogen bonds involving uracil and ribose moieties have been found to play an important role in the stabilization of the nucleoside. |
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| Keywords: | conformational analysis hydrogen bonds laser ablation microwave spectroscopy nucleosides |
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