Stereoselective Synthesis of N~1-Lyxitol Inosine Derivative |
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Authors: | Li Jun HUANG Yan PANG Ji Mei MIN Li He ZHANG National Research Laboratory of Natural Biomimetic Drugs Peking University Beijing |
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Affiliation: | Li Jun HUANG,Yan PANG,Ji Mei MIN,Li He ZHANG* National Research Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100083 |
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Abstract: | anhydro-2-triflyl-3,5-O-benzenylidene-L-xylitol (5) was constructed in six steps from protected D-xylose. Substitution of 5 with protected 8-bromoinosine 6 gave the key intermediate 5'-O-TBS-2',3'-di-O-acetyl-N1-(2'-deoxy-1",4"-anhydro-3',5'-O-benzenylidene-L- lyxitol-2'-yl)-8-bromoinosine (14). Selective removal of 5'-O-TBS-group gave the corresponding 5'-O-phosphorodianilidate 4 though phosphorylation, which was characterized by X-ray crystallographic analysis. |
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Keywords: | Cyclic ADP-ribose analogues synthesis X-ray crystallographic analysis. |
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