Solvent effects in lipase-catalysed transesterification reactions |
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| Authors: | L T Kanerva J Vihanto M H Halme J M Loponen E K Euranto |
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| Affiliation: | Department of Chemistry, University of Turku, Finland. |
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| Abstract: | Porcine pancreatic lipase-catalysed transesterifications of 2,2,2-trifluoroethyl butyrate with racemic 2-octanol and 1-phenylethanol have been studied in different organic solvents. Solvent hydrophobicity (log P -1.1 to 3.3) has only a minor effect on the reaction rate. Independently of the solvent used as the reaction medium, both (R)-2-octyl and (R)-1-phenylethyl butyrates were obtained in high optical purity (ee greater than 90%). Candida cylindracea lipase is active only in the most hydrophobic solvents studied. |
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