| 新型NO供体的合成及其体外释放NO性能 |
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| 引用本文： | 刘自兵,冯清,杨琴,夏淑贞,田少林,朱伟雄,王懿. 新型NO供体的合成及其体外释放NO性能[J]. 应用化学, 2006, 23(5): 508-0 |
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| 作者姓名： | 刘自兵 冯清 杨琴 夏淑贞 田少林 朱伟雄 王懿 |
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| 作者单位： | 华中科技大学a化学系；b同济医学院 |
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| 基金项目： | 湖北省科技攻关重点项目(20002P0325)，湖北省自然科学基金资助项目(2005ABA173) |
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| 摘 要： | 新型NO供体的合成及其体外释放NO性能;金属卟啉;NO载体;合成;体外释NO作用
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| 关 键 词： | 新型NO供体的合成及其体外释放NO性能 金属卟啉 NO载体 合成 体外释NO作用 |
| 文章编号： | 1000-0518(2006)05-0508-06 |
| 收稿时间： | 2005-06-30 |
| 修稿时间： | 2005-09-28 |
Synthesis and NO-Releasing of Nitrosyl Metalloporphyrins |
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| LIU Zi-Bing,FEN Qing,YANG Qin,XIA Shu-Zhen,TIAN Shao-Lin,ZHU Wei-Xiong,WANG Yi. Synthesis and NO-Releasing of Nitrosyl Metalloporphyrins[J]. Chinese Journal of Applied Chemistry, 2006, 23(5): 508-0 |
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| Authors: | LIU Zi-Bing FEN Qing YANG Qin XIA Shu-Zhen TIAN Shao-Lin ZHU Wei-Xiong WANG Yi |
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| Affiliation: | 1,Departement of Chemistry ;2, Tongji Medical College, Huazhong University of Science and Techmology, Wuhan 430074 |
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| Abstract: | Meso-5,10,15,20-tetra(4-hydroxylphenyl) porphyrin(H_(2)THPP) and meso-5,10,15,20-tetra(4-aminophenyl) porphyrin(H_(2)THPP) were synthesized with the method described in the references.The metalloporphyrin complexes were prepared via the solid-state reactions of the porphyrins with Cu(Ac)_(2),(Mn(Ac)_2),Fe(Ac)_(2) or Co(Ac)_(2) and purified by using column chromatography,and the correspending(nitrosyl) metalloporphyrin complexes were synthesized by combining the metalloprphyrin complexes with nitric oxide.The structures of the above synthetic products were characterized by means of FT-IR,~(1)H NMR,MS and(elemental) analysis.The NO-releasing properties of the nitrosyl metalloporphyrins in aqueous solutions were studied by(diazotization) at room temperature.The results show that NO-releasing efficiencies of THPP-CoNO,THPP-Fe-NO,TNPP-Co-NO and TNPP-Fe-NO were 59.48%,66.42%,63.17% and 62.04% respectively. |
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| Keywords: | metalloporphyrin nitric oxide carrier synthesis NO-releasing in vitro |
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