Green synthesis of benzimidazole derivatives catalyzed by ionic liquid under microwave irradiation |
| |
Authors: | Mingcong Qin Yujie Fu Xiqing Wang Yuhang Zhang Weidong Ma |
| |
Affiliation: | 1. State Engineering Laboratory of Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, 150040, People’s Republic of China 2. Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, People’s Republic of China
|
| |
Abstract: | An efficient synthesis of benzimidazole derivatives from o-phenylene diamine and substituted aromatic aldehyde catalyzed by ionic liquid under microwave irradiation was reported. The synthesis conditions were first optimized by single factor experiments. Then, a central composite design combined with response surface methodology was used to study the most effective factors. Optimal conditions were synthesis time 1 h, the reactant/catalyst molar ratio 1:1:0.200, the temperature 50 °C and the microwave power 500 W. Under optimized conditions, the yields of benzimidazole derivatives were 78.55–97.66 %. This method offered the outstanding advantages, such as faster reaction rate, higher yields, recyclable catalyst, environmental friendliness, and simple workup procedure. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|