Syntheses and structures of organic-inorganic hybrid compounds based on metal-fluconazole coordination polymers and the beta-Mo8O26 anion

Five organic-inorganic hybrid compounds, namely, Co2(fcz)4(H2O)4]beta-Mo8O26].5H2O (1), Ni2(fcz)4(H2O)4]beta-Mo8O26].5H2O (2), Zn2(fcz)4(beta-Mo8O26)].4H2O (3), Cu2(fcz)4(beta-Mo8O26)].4H2O (4), and Ag4(fcz)4(beta-Mo8O26)] (5), where fcz is fluconazole 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol], were synthesized under hydrothermal conditions, and crystal structures of 1-5 have been determined by X-ray diffraction. In compounds 1 and 2, metal cations are linked by fluconazole ligands to form hinged chain structures and beta-Mo8O26]4- anions act as counterions. In compound 3, Zn(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and each pair of these networks is linked by beta-Mo8O26]4- anions to form a sandwich double-layer structure. In compound 4, Cu(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and these networks are connected by beta-Mo8O26]4- anions to form a 3D framework. In compound 5, AgI cations and Ag2]2+ units are bridged by fluconazole ligands to form 2D Ag-fcz layers, and these layers are further connected by beta-Mo8O26]4- anions to form a complicated 3D structure with the topology of (7(2).8(1))2(7(3).8(3))(7(2).8(11).10(1).12(1))2. Thermogravimetric analyses for these compounds are also discussed in detail. The complexes exhibit antitumor activity in vitro, as shown by MTT experiments.