A highly diastereoselective MgI2-mediated ring expansion of methylenecyclopropanes |
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| Authors: | Scott Mark E Han Wooseok Lautens Mark |
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| Institution: | Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. |
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| Abstract: | reaction: see text] A highly diastereoselective MgI(2)-mediated ring expansion of methylenecyclopropane amides to functionalized pyrrolidines has been developed using chiral aromatic sulfinimines. The 2,3,4-trisubstituted pyrrolidines were isolated in generally good to excellent yields and in excellent diastereoselectivities for aromatic and heterocyclic sulfinimines. |
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