Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene-3-fluoroalkyl-3-oxopropionates |
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| Authors: | M. V. Pryadeina Ya. V. Burgart M. I. Kodess V. I. Saloutin |
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| Affiliation: | (1) I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi/Akademicheskaya, 620219 Ekaterinburg, Russian Federation |
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| Abstract: | Cyclocondensation of 2-arylmethylidene-3-fluoroalkyl-oxopropionates with 2-amino-pyridine occurs at both the polyfluoroacylvinyl and alkoxycarbonylvinyl fragments to give alkyl 4-aryl-2-polyfluoroalkyl-4H-pyrido[1,2-a]pyrimidine-3-carboxylates and 4-aryl-2-hydroxy-3-polyfluoroacyl-4H-pyrido[1,2-a]pyrimidines, respectively. When treated with copper(II) acetate, the pyrido[1,2-a]pyrimidines yield metal complexes. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2745–2749, December, 2005. |
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| Keywords: | cyclocondensation regioisomerism 2-arylmethylidene-3-fluoroalkyl-3-oxopropionate 2-aminopyridine pyrido[1,2-a]pyrimidine complex formation |
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