| 用循环拆分法制备手性萘乙胺 |
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| 引用本文： | 胡键,董菁,施小新.用循环拆分法制备手性萘乙胺[J].合成化学,2010,18(1). |
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| 作者姓名： | 胡键 董菁 施小新 |
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| 作者单位： | 华东理工大学,药学院,上海,200237 |
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| 基金项目： | 国家自然科学基金资助项目，上海市教育发展基金资助项目 |
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| 摘 要： | 研究了1-(1-萘基)乙胺(RS)-1]和1-(2-萘基)乙胺(RS)-2]的循环拆分方法。以D-酒石酸为拆分剂,分别拆分(RS)-1和(RS)-2得到了(R)-1-(1-萘基)乙胺(收率31%,98%ee)和(R)-1-(2-萘基)乙胺(收率30%,98%ee),并对母液中的非目标对映异构体成功的进行了消旋化,实现了循环拆分。
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| 关 键 词： | 萘乙胺 拆分 循环拆分 消旋 |
Preparation of Chiral Naphthylethylamines by Recycling Resolution |
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| HU Jian,DONG Jing,SHI Xiao-xin.Preparation of Chiral Naphthylethylamines by Recycling Resolution[J].Chinese Journal of Synthetic Chemistry,2010,18(1). |
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| Authors: | HU Jian DONG Jing SHI Xiao-xin |
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| Abstract: | The recycling resolution of (RS)-1-(1-naphthyl)ethylamine(RS)-1] and (RS)-1-(2-naphthyl)ethylamine(RS)-2] was studied in this paper.(R)-1-(1-naphthyl)ethylamine(31% yield,98%ee) and (R)-1-(2-naphthyl)ethylamine(30% yield,98%ee) were obtained via resolution of the racemic (RS)-1 and (RS)-2 by using D-tartaric acid as a resoluting agent.Meanwhile racemization of the non-target enantiomeric isomers from mother liquor was performed,and the recycling resolution was realized. |
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| Keywords: | naphthylethylamine resolution recycling resolution racemization |
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