Synthesis of amphidinolide T1 via catalytic, stereoselective macrocyclization |
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Authors: | Colby Elizabeth A O'Brien Karen C Jamison Timothy F |
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Institution: | Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, USA. |
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Abstract: | Two nickel-catalyzed reductive coupling reactions of alkynes were instrumental in a modular, stereoselective synthesis of amphidinolide T1 (1). The C13-C21 fragment was prepared from two simple starting materials that were joined in a catalytic alkyne-epoxide fragment coupling operation, whereas an intramolecular aldehyde-alkyne reductive coupling simultaneously formed the final carbon-carbon bond of the macrocycle and established the C13 carbinol configuration with complete selectivity in the desired fashion. |
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