以大蓟髓芯为模板制备复合孔生物活性玻璃及其体外成骨性能

以天然植物大蓟髓芯为大孔模板, 以嵌段共聚物为介孔软模板, 制备了孔径为60~100 μm、孔壁为介孔相的高度有序多级复合孔生物活性玻璃. 用扫描电子显微镜(SEM)、粉末X射线衍射仪(XRD)、高分辨率透射电镜(HRTEM)及N2吸附-脱附等测试手段对合成的样品进行了表征. 结果表明， 合成的材料精确地复制了植物模板的形貌, 同时具有较高的比表面积和较大的孔容. 通过体外模拟生理体液测试表明, 这种复合孔生物活性玻璃可诱导羟基磷灰石晶体在其表面形成, 具有良好的体外成骨性能, 因而在骨组织修复方面具有潜在应用前景.

Preparation of Composite Porous Bioactive Glass Using Cirsium as Template and Osteogenesis in vitro

The highly ordered composite porous bio-glass was successfully prepared using the pith of cirsium and P123 as co-templates. It exhibits a hierarchical structure with macropores of 60—100 μm and mesoporous phase in the inner walls of macropores. The sample was characterized by scanning electron microscopy(SEM), powder X-ray diffraction(XRD), transmission electron microscopy(TEM) and N2 adsorption/desorption and so on. The results indicate that the sample replicated the morphologies of plant templates precisely, meanwhile, the material possessed larger specific BET surface area and porous volume. In vitro simulate body fluid(SBF) test shows that the bioactive glass can induce the formation of hydroxyapatite(HAP) on their surface, which has good bioactivity of osteogenesis. Therefore, the material may have potential application in tissue regeneration engineering.