New constituents from the leaves of Morinda citrifolia |
| |
Authors: | Takashima Junko Ikeda Yoshitaka Komiyama Kanki Hayashi Masahiko Kishida Akio Ohsaki Ayumi |
| |
Affiliation: | Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp |
| |
Abstract: | A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|