HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong |
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| Authors: | S Zschocke I Klaiber R Bauer B Vogler |
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| Institution: | (1) Institut für Chemie, Universität Hohenheim, Stuttgart, Germany;(2) Institut für Pharmakognosie, Karl-Franzens-Universität Graz, Austria;(3) Department of Chemistry, University of Alabama in Huntsville, USA |
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| Abstract: | Ligusticum chuanxiong Hort., a plant that is frequently used in traditional Chinese medicine, has been studied using HPLC-coupled spectroscopic techniques such as HPLC-UV, HPLC-MS as well as HPLC-NMR. With the aid of these modern spectroscopic techniques, the main constituents, namely senkyunolide A, butylphthalide, neocnidilide and Z-ligustilide, have been characterized and identified. Phthalide dimers, present in smaller amounts, have been identified by HPLC-UV and HPLC-MS analysis and compared with reference compounds. Stereochemical features of some phthalide monomers have been determined by detailed spectroscopic studies for the first time. |
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| Keywords: | dereplication HPLC-MS HPLC-NMR HPLC-UV Ligusticum chuanxiong phthalides online-coupled spectroscopy |
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