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How to find "missing" genes
Authors:Gerlt John A
Institution:Department of Biochemistry, University of Illinois, 415 Roger Adams Laboratory, 600 S Mathews Avenue, Urbana, IL 61801, USA.
Abstract:Assigning function to "new" proteins is frequently the rate-determining step for deciphering metabolic pathways and regulatory networks. Osterman and Begley break down this barrier by demonstrating that comparative analyses of microbial genomes is a powerful strategy for identifying pathway components.
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