| 聚天冬氨酸修饰对磁性氧化铁纳米粒子稳定性及脑MRI造影效果的影响 |
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| 引用本文： | 孙琳,刘桂峰,庄家骐,张惠茅,杨文胜. 聚天冬氨酸修饰对磁性氧化铁纳米粒子稳定性及脑MRI造影效果的影响[J]. 高等学校化学学报, 2010, 31(12): 2313-2315 |
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| 作者姓名： | 孙琳 刘桂峰 庄家骐 张惠茅 杨文胜 |
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| 作者单位： | 1. 吉林大学化学学院,长春,130012
2. 吉林大学中日联谊医院,长春,130033 |
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| 基金项目： | 国家自然科学基金(批准号:50902058,50825202)资助 |
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| 摘 要： | <正>超顺磁性氧化铁(Superparamagnetic iron oxide,SPIO)作为医用磁共振成像(Magnetic resonance imaging,MRI)造影剂,可以有效地改变人体组织中质子的自旋-自旋弛豫时间,从而增强磁共振成像的对
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| 关 键 词： | 超顺磁性氧化铁 聚天冬氨酸 核磁共振成像 造影剂 |
| 收稿时间： | 2010-08-31 |
Effect of Polyaspartic Acid Modification on Stability and MRI Enhancement of Magnetic Iron Oxide Nanoparticles |
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| SUN Lin,LIU Gui-Feng,ZHUANG Jia-Qi,ZHANG Hui-Mao,YANG Wen-Sheng. Effect of Polyaspartic Acid Modification on Stability and MRI Enhancement of Magnetic Iron Oxide Nanoparticles[J]. Chemical Research In Chinese Universities, 2010, 31(12): 2313-2315 |
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| Authors: | SUN Lin LIU Gui-Feng ZHUANG Jia-Qi ZHANG Hui-Mao YANG Wen-Sheng |
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| Affiliation: | SUN Lin2,LIU Gui-Feng1,ZHUANG Jia-Qi2,ZHANG Hui-Mao1,YANG Wen-Sheng2(1.China-Japan Union Hospital,Jilin University,Changchun 130033,China,2.College of Chemistry,Changchun 130012,China) |
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| Abstract: | Polyaspartic acid(PSAP) was employed to modify the surface of superparamagnetic iron oxide(SPIO).The colloidal stability of SPIO could be adjusted by the amount of PSAP and the modified SPIO showed improved stability under physiological condition.Magnetic resonance imaging(MRI) experiments of rabbit brain demonstrate that the PSAP modified SPIO can be well dispersed into the brain tissue,resulting in enhanced contrast of the MRI images. |
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| Keywords: | Superparamagnetic iron oxide Polyaspartic acid Magnetic resonance imaging Contrast agent |
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