A review of direct liquid introduction interfacing for LC/MS Part II: Mass spectrometry and applications

Summary The coupling liquid chromatography and mass spectrometry is still growing in popularity. Direct liquid introduction has become one of the most important interfaces in LC/MS coupling. The various aspects of the interface have been investigated by several groups. This paper is the second part of a review of the developments in direct liquid introduction. Instrumental aspects of direct liquid introduction interfacing were discussed in the first part. This part will deal with the mass spectrometric aspects, i.e. chemical ionization and the influence of the various experimental conditions on the spectra. The applications of direct liquid introduction will also be reviewed briefly.