Proficiency testing schemes for therapeutics and toxicology |
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Authors: | David W Holt |
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Institution: | (1) Analytical Unit, Department of Cardiological Sciences, St. George's Hospital Medical School, London SW17 0RE, UK e-mail d.holt@sghms.ac.uk Tel: +44-20-8767 9686 Fax: +44-20-8767 9687, GB |
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Abstract: | This report addresses the proposition: current proficiency testing (PT) schemes for therapeutics and toxicology can easily
engender complacency. The proposition was based on the premise that there are substantial between-laboratory differences and
objectives in the supply of services for the measurement of drugs, as a result of which it is difficult to design PT schemes
which adequately cover the requirements of all laboratories. Thus, acceptable performance in a PT scheme may lead participants
to consider that they have tested their procedures more rigorously than is the case. Four areas, validity of the PT scheme,
PT material, frequency of testing and acceptance criteria are examined.
Received: 15 April 2000 · Accepted: 15 April 2000 |
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Keywords: | Proficiency testing Matrix effects Therapeutic drug monitoring Toxicology acceptance criteria |
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