| 小鼠大脑急性缺血过程中31P NMR研究 |
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| 引用本文： | 田建广,杜泽涵.小鼠大脑急性缺血过程中31P NMR研究[J].波谱学杂志,1998,15(6):521-526. |
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| 作者姓名： | 田建广 杜泽涵 |
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| 作者单位： | 军事医学科学院 国家生物医学分析中心, 北京 100850 |
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| 摘 要： | 利用31P NMR研究了小鼠大脑在急性缺血状态下能量代谢的特点,结扎带迷走神经的颈总动脉后,PCr/Pi、β-ATP/Pi比值迅速下降,且PCr/Pi下降速度较快,同时脑细胞内酸中毒加重.缺血5min后恢复供血,可部分地逆转缺血造成的损伤.
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| 关 键 词： | 小鼠大脑 急性缺血 31P NMR |
| 收稿时间： | 1998-05-08 |
STUDIES OF 31 P MRS OF MOUSE BRAIN DURING ACUTE ISCHEMIA |
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| Tian Jianguang,Du Zehan ,Feng Rui and Li Guangyu.STUDIES OF 31 P MRS OF MOUSE BRAIN DURING ACUTE ISCHEMIA[J].Chinese Journal of Magnetic Resonance,1998,15(6):521-526. |
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| Authors: | Tian Jianguang Du Zehan Feng Rui and Li Guangyu |
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| Institution: | National Center for Biomedical Analysis, Beijing 100850 |
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| Abstract: | The characteristics of energy metabolism of mouse brain during acute ischemia was studied using 31P NMR.After the ligation of two-sided common carotid artery along with vagus, PCr/Pi、β-ATP/Pi ratios decreased dramatically,and PCr/Pi ratio decreased faster,at the same time brain cells suffered acidosis.Reperfusion after 5min ischemia can partly reverse the injury caused by ischemia. |
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| Keywords: | Mouse brain Acute ischemia 31 P MRS |
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