天然植物高分子药用胶囊的研究与发展

讨论了天然植物高分子药用胶囊的最新研究与发展,介绍了目前的主要研究成果并提出展望.不仅从化学结构、流变和相变等基础理论方面探讨了各类植物药用胶囊的特性和研制中所遇到的问题,同时对各种胶囊制备设备与工艺的发展及应用中的技术改进进行了综述分析.传统明胶胶囊生产工艺的应用已有160多年的历史,目前植物胶囊生产设备和工艺多是建立在传统明胶胶囊生产的基础上.研究植物胶囊材料的流变和凝胶性能以尽量满足传统明胶的设备与工艺是当今急需解决的难题之一.近年来,随着人们对淀粉结构和改性方法的深入研究(尤其是将淀粉基可生物降解材料的制备技术与传统食品科学的研究成果有效结合),应用高分子科学理论和方法提高淀粉基材料的加工性能,力学性能与稳定性的研究有了突破性进展,为淀粉胶囊的研制提供了理论和技术上的有力支持.使用传统塑料加工的挤出加工法制备植物胶囊,是植物胶囊研究中的重大突破和创新.从原材料来源的充足性和价格上考虑,淀粉是最有潜力替代传统胶囊的原料之一.

DEVELOPMENT OF CAPSULES FROM NATURAL PLAN POLYMERS

The higher price of raw materials and the well-recognized shortcomings of gelatin capsules,such as animal-derived ingredients,lower soft temperature and the instability of moisture in gelatin,have led to attempts to develop replacement substances,such as various vegetable gums,hydroxypropyl methylcellulose cellulose and modified starch.Although there are many patents and publications on the developing various substances for capsules,only a few non-gelatin capsule products have recently entered the market.The reasons for the lower commercial success include the higher price of these new products due to requirements for new processing facilities,and/or more complex processing conditions.This paper discusses the development of capsules made from various natural plant polymers,including both fundamental science such as microstructure,phase transition and rheology,as well as processing techniques and formulations.As one of the most popular food ingredients and has good film-forming behavior,starch has shown great potential.The achievements in this area have increased our knowledge of polymer science,in particular that of natural polymers.Application of extrusion technique in capsule manufacture is a significant achievement.