| 醋酸特拉司酮的合成 |
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| 引用本文： | 任学状,李雁武,郭卿,袁勇,袁建勇. 醋酸特拉司酮的合成[J]. 化学通报, 2015, 78(12): 1108-1112 |
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| 作者姓名： | 任学状 李雁武 郭卿 袁勇 袁建勇 |
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| 作者单位： | 重庆医科大学药学院,重庆医科大学药学院,重庆医科大学药学院,重庆医科大学药学院,重庆医科大学药学院 |
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| 基金项目： | 重庆市教委技术研究项目（KJZH14204）资助 |
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| 摘 要： | 以醋酸乌利司他为起始原料,乙二醇选择性保护3-羰基得到缩酮物,然后经21-甲基碘代、取代、水解、甲基化,最后脱保护,酯化得到醋酸特拉司酮。
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| 关 键 词： | 醋酸特拉司酮 醋酸乌利司他 合成 |
| 收稿时间： | 2015-05-07 |
| 修稿时间： | 2015-07-04 |
Synthesis of telapristone acetate |
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| Ren Xuezhuang,Li Yanwu,Guo Qing,Yuan Yong and Yuan Jianyong. Synthesis of telapristone acetate[J]. Chemistry, 2015, 78(12): 1108-1112 |
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| Authors: | Ren Xuezhuang Li Yanwu Guo Qing Yuan Yong Yuan Jianyong |
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| Affiliation: | Pharmacy College,Chongqing Medical University,Pharmacy College,Chongqing Medical University,Pharmacy College,Chongqing Medical University,Pharmacy College,Chongqing Medical University,Pharmacy College,Chongqing Medical University |
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| Abstract: | Telapristone acetate was synthesized from ulipristal acetate as the starting material through protection of the 3-Carbonyl group, iodination, substitution, methylation, deprotection of 3-carbonyl and acetylation of 17-hydroxy group. |
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