Molecular mechanisms of photochemotherapy (Review) |
| |
Authors: | G A Zalesskayaa and V S Ulashchik |
| |
Institution: | (1) B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 68 Nezavisimosti Ave., Minsk, 220072, Belarus;(2) Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus |
| |
Abstract: | Mechanisms of photophysical, photobiological, and therapeutic action of light on blood in vivo are discussed based on results
of spectral and clinical studies of blood, plasma, and erythrocytes. Spectral manifestations of photochemical reactions initiated
in blood by therapeutic doses of radiation in vivo with light of different wavelengths are considered. Spectral and clinical
results of blood investigations are compared for patients whose complex treatment included intravenous blood irradiation and
magnetotherapy. Mechanisms for secondary (dark) reactions induced by the action of light on blood in vivo are discussed. The
radiation of laser and non-laser light sources used at present for intravenous blood irradiation (365, 405, 450, 530, 632,
635, 808 nm) is shown to fall within hemoglobin absorption bands. The conclusion is made that blood absorption of laser and
non-laser light radiation results in functional alteration of hemoglobin as a possible primary photoacceptor absorbing light
radiation of the above wavelengths. The therapeutic effect of intravenous blood irradiation is initiated by hemoglobin functional
activity modulation. Phototherapy is a means to correct it. Intravenous phototherapy should be considered as a therapeutic
method that changes (provided that the dosage is correct) the balance of active oxygen species production and their inhibition
by antioxidants.
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 76, No. 1, pp. 51–75, January–February, 2009. |
| |
Keywords: | phototherapy intravenous blood irradiation UV-visible spectra of blood infrared spectra hemoglobin spectra plasma luminescence spectrum active oxygen species lipid peroxidation oxidative stress |
本文献已被 SpringerLink 等数据库收录! |
|