Capillary Electrophoretic Determination of Gatifloxacin from Pharmaceutical Preparation |
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Authors: | R T Sane S Menon A R Pathak A Y Deshpande M Mahale |
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Institution: | (1) Department of Chemistry, Ramnarain Ruia College, Matunga, Mumbai, 400019, India;(2) Therapeutic Drug Monitoring Laboratory, 194, Scheme No. 6, Road No.15, Sion (E), Mumbai, 400 022, India |
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Abstract: | Capillary zone electrophoresis has been used for the determination of gatifloxacin from its pharmaceutical preparation (tablets), using fused silica capillary. Separation was performed after hydrodynamic injection; the separation was achieved by applying 21 Kv voltage. Phosphate buffer solution (pH 9.5) was used as separation electrolyte. Detection was at 280 nm using a UV- detector. Under these experimental conditions the analysis takes 8 min. A linearity range for gatifloxacin was between 20.0 g mL–1 to 60.0 g mL–1. The method was validated and was found to be specific, precise, accurate, reproducible and robust and can be applied for the routine analysis of gatifloxacin from formulation and bulk drug. |
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Keywords: | Capillary zone electrophoresis Gatifloxacin and ciprofloxacin Tableti formulations |
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